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Pains from darkness to daylight; begin with twilight and end with daylight (Merc., Phyt.). Pains increase and decrease gradually (Stan.); shifting and require frequent change of position. All symptoms are worse at night (Merc.); from sundown to sunrise. Eruptions: dull, red, copper-colored spots, becoming blue when getting cold. Extreme emaciation of entire body (Abrot., Iod.). Heart: lancinating pains from base to apex, at night (from apex to base, Med.; from base to clavicle or shoulder, Spig.). Loss of memory; cannot remember names of books, persons or places; arithmetical calculation difficult. Sensation: as if going insane, as if about to be paralyzed; of apathy and indifference. Terrible dread of night on account of mental and physical exhaustion on awakening; it is intolerable, death is preferable. Fears the terrific suffering from exhaustion on awakening (Lach.). Leucorrhoea; profuse; soaking through the napkins and running down the heels (Alum.). Headache, neuralgic in character, causing sleeplessness and delirium at night; commencing at 4 p. m.; worse from 10 to 11 and ceasing at daylight (ceases at 11 or 12 p. m., Lyc.); falling of the hair. Acute ophthalmia neonatorum; lids swollen, adhere during sleep; pain intense at night < from 2 to 5 a. m., pus profuse; > by cold bathing. Ptosis: paralysis of superior oblique; sleepy look from drooping lids (Caust., Graph.). diplopia, one image seen below the other. Teeth: decay at edge of gum and break off; are cupped, edges serrated; dwarfed in size, converge at their tips (Staph.). Craving alcohol, in any form. Hereditary tendency to alcoholism (Asar., Psor., Tuber., Sulph., Sulph. ac.). Obstinate constipation for year; rectum seems tied up with strictures; when enema was used the agony of passage was like labor (Lac. c., Tub.). Fissures in anus and rectum (Thuja); prolapse of rectum; obstinate cases with a syphilitic history. Rheumatism of the shoulder joint, or at insertion of deltoid, < from raising arm laterally (Rhus - right shoulder, Sang.; left, Fer.). When the best selected remedy fails to relieve or permanently improve, in syphillitic affections. Syphilitics, or patients who have had chancre treated by local means, and as a result have suffered from throat and skin troubles for years, are nearly always benefited by this remedy at commencement of treatment unless some other remedy is clearly indicated.

< At night, from twilight to daylight.